The clinical development of anti-PD-L1 agents is at the epicenter of immuno-oncology drug development. The clinical success of monoclonal antibodies targeting PD-L1 is an attractive lure, and drug development in this sphere continues at a robust pace. The Anti-CD274 (PD-L1) Antibody pipeline constitutes 80+ key companies proactively working to develop 80+ key therapies, asserts DelveInsight.
DelveInsight’s Anti-CD274 (PD-L1) Antibody Pipeline Insight 2022 report offers exhaustive global coverage of available, marketed, and pipeline therapies in different phases of clinical development, major pharmaceutical companies working to advance the pipeline space, and future growth potential of the Anti-CD274 (PD-L1) Antibody pipeline domain.
Some of the essential takeaways from the Anti-CD274 (PD-L1) Antibody Pipeline report:
- DelveInsight’s Anti-CD274 (PD-L1) Antibody Pipeline analysis depicts a robust space with 80+ active players working to develop 80+ pipeline treatment therapies.
- Some of the key pharmaceutical companies working to develop potential drug candidates to improve the Anti-CD274 (PD-L1) Antibody treatment scenario include Compass Therapeutics, Curis, Biotheus, RemeGen, Incyte Corporation, Jubilant Therapeutics, ChemoCentryx, ABL Bio, Chia Tai Tianqing Pharmaceutical, Jiangsu Hengrui Medicine, Sorrento Therapeutics, CStone Pharmaceuticals, Celgene, Checkpoint Therapeutics, Alphamab Oncology, Eli Lilly and Company, Novartis Pharmaceuticals, Aurigene Discovery Technologies, Arbutus Biopharma, CytomX Therapeutics, Genmab A/S, Secarna Pharmaceuticals, Avacta Life Sciences Limited, Fate Therapeutics, Hanmi Pharm.Co., Ltd., Celldex Therapeutics, Bolt Biotherapeutics, Bio-Thera Solutions, Acepodia Inc., Janux Therapeutics, Coherus Biosciences, Effector Therapeutics, Palleon Pharmaceuticals, F-star Therapeutics, BeiGene, and many others.
- Essential Anti-CD274 (PD-L1) Antibody pipeline therapies such as CTX-8371, CA 327, RC 98, PM 8001, INCB086550, CCX 559, ABL501, TQB 2450, SHR 1316, FS222, SHR-1701, Cosibelimab, LY 3434172, KN035, KN046, CX-072, GEN1046, AVA028, AVA021, PD-L1 XT, FT516, FT500, CDX 527, Envafolimab, BGB-A333, ACE1708, Tomivosertib, and others are under development in different phases of clinical trials.
- In November 2021, Sorrento Therapeutics announced that its license partner, China Oncology Focus Limited (COF), an affiliate of Lee’s Pharmaceutical Holdings Limited has submitted an NDA (new drug application) for the anti-PD-L1 antibody, socazolimab, licensed from Sorrento to COF for the greater China territory to treat recurrent or metastatic cervical cancer. The NDA application has been accepted by China NMPA. In February 2021, Sorrento and Lee’s Pharma announced that socazolimab had been granted breakthrough designation by the NMPA.
- In December 2021, Checkpoint Therapeutics announced the initiation of the CONTERNO study, a global, randomized Phase 3 trial of cosibelimab in combination with pemetrexed and platinum chemotherapy for the first-line treatment of patients with non-squamous non-small cell lung cancer (NSCLC). The primary endpoint for the CONTERNO Phase 3 trial is overall survival (OS), and the study is designed to support full regulatory approvals worldwide.
- In August 2021, ABL Bio announced that the Investigational New Drug (IND) application for ABL501 has been approved by South Korea’s Ministry of Food and Drug Safety (MFDS).
- In December 2021, Biotheus Inc. announced that its proprietary anti-PD-L1/TGF-β bifunctional therapeutic, named PM8001, has been approved by the USFDA (United States Food and Drug Administration) for conducting clinical phase II studies as part of an international multicenter clinical trial.
- In September 2021, Chia Tai Tianqing Pharmaceutical Group initiated a Phase III clinical study to evaluate the efficacy and safety of TQB2450 injection combined with Anlotinib Hydrochloride capsules versus weekly treatment with paclitaxel of recurrent platinum-resistant ovarian cancer. The trial is currently active with 405 participants and is anticipated to be completed by December 2024.
- In June 2021, Alphamab Oncology announced that FDA approved an Orphan Drug Designation (ODD) to envafolimab (KN035), a recombinant humanized PD-L1 single-domain antibody independently invented by Alphamab Oncology, for the treatment of patients with soft tissue sarcoma. This is the second Orphan Drug Designation for Envafolimab after its first ODD in advanced biliary tract cancer and the fourth ODD that Alphamab Oncology has obtained from the U.S. FDA.
View Report: https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight
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The Anti-CD274 (PD-L1) Antibody pipeline report lays down detailed profiles of the pipeline assets, comparative analysis of clinical and non-clinical stage Anti-CD274 (PD-L1) Antibody products, inactive and dormant assets, comprehensive assessment of driving and restraining factors, as well as the opportunities and risks in the Anti-CD274 (PD-L1) Antibody pipeline landscape.
Anti-CD274 (PD-L1) Antibody Overview
Programmed death-ligand 1 (PD-L1; and its partner PD-L2) is a transmembrane protein expressed in normal tissues to inhibit the activity of T-cells and prevent autoimmunity. PD-L1 is commonly upregulated on the surface of tumor cells, binding to the programmed death 1 (PD-1) expressed on tumor-infiltrating lymphocytes, eventually causing a T-cell tolerance. This represents one of the various mechanisms of immune evasion. The molecular organization of PD-L1 is similar to that of other B7 molecules and typical of the immunoglobulin superfamily. PD-L1 is constitutively expressed at varying levels in cells of the myeloid lineage, such as DCs, macrophages, and myeloid-suppressor cells (MDSCs) but also in other cell types.
Find out more about the disease and recent developments @ Anti-CD274 (PD-L1) Antibody Pipeline Assessment
View Report: https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight
Anti-CD274 (PD-L1) Antibody Pipeline Drugs
| Drug | Company | Phase | MoA | RoA |
| CTX-8371 | Compass Therapeutics | Preclinical | Programmed cell death-1 ligand-1 inhibitors | NA |
| CA 327 | Curis | Preclinical | Programmed cell death-1 ligand-1 inhibitors | Oral |
| RC 98 | RemeGen | Phase I | Programmed cell death-1 ligand-1 inhibitors | Parenteral |
| LY 3434172 | Eli Lilly and Company | Phase I | Programmed cell death-1 ligand-1 inhibitors | Intravenous |
| INBRX-105 | Inhibrx | Phase I | Programmed cell death-1 ligand-1 inhibitors | Parenteral |
| CDX 527 | Celldex Therapeutics Inc | Phase I | Programmed cell death-1 ligand-1 inhibitors | Parenteral |
| PM 8001 | Biotheus | Phase II | Programmed cell death-1 ligand-1 inhibitors | Parenteral |
| INCB086550 | Incyte Corporation | Phase II | Programmed cell death-1 ligand-1 inhibitors | Oral |
| CX-072 | CytomX Therapeutics | Phase II | Programmed cell death-1 ligand-1 inhibitors | Intravenous |
| Tomivosertib | Effector Therapeutics | Phase II | Programmed cell death-1 ligand-1 inhibitors | Oral |
| Research program: programmed cell death 1 ligand 1 inhibitors | Jubilant Therapeutics | Preclinical | Programmed cell death-1 ligand-1 inhibitors | NA |
| CCX 559 | ChemoCentryx | Phase I | Programmed cell death-1 ligand-1 inhibitors | Oral |
| ABL501 | ABL Bio | Phase I | Programmed cell death-1 ligand-1 inhibitors | Parenteral |
| TQB 2450 | Chia Tai Tianqing Pharmaceutical | Phase III | Programmed cell death-1 ligand-1 inhibitors | Intravenous |
| SHR 1316 | Jiangsu Hengrui Medicine | Phase III | Programmed cell death-1 ligand-1 inhibitors | Parenteral |
| SHR-1701 | Jiangsu Hengrui Medicine | Phase III | Programmed cell death-1 ligand-1 inhibitors | Intravenous |
| Cosibelimab | Checkpoint Therapeutics | Phase III | Programmed cell death-1 ligand-1 inhibitors | Intravenous |
| Socazolimab | Sorrento Therapeutics | Preregistration | Programmed cell death-1 ligand-1 inhibitors | Intravenous |
| GB226 | Genor Biopharma | Preregistration | Programmed cell death-1 ligand-1 inhibitors | Intravenous |
| BGB-A333 | BeiGene | Phase I/II | Programmed cell death-1 ligand-1 inhibitors | Intravenous |
Learn more about the novel and emerging Anti-CD274 (PD-L1) Antibody pipeline therapies @ https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight
Anti-CD274 (PD-L1) Antibody Therapeutics Assessment
The Anti-CD274 (PD-L1) Antibody Pipeline report proffers an integral view of the Anti-CD274 (PD-L1) Antibody emerging novel therapies segmented by Stage, Product Type, Molecule Type, Mechanism of Action, and Route of Administration.
View Report: https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight
Scope of the Anti-CD274 (PD-L1) Antibody Pipeline Report
- Coverage: Global
- Therapeutic Assessment By Anti-CD274 (PD-L1) Antibody Product Type: Mono, Combination, Mono/Combination
- Therapeutic Assessment By Anti-CD274 (PD-L1) Antibody Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III, Pre-registration,Inactive candidates
- Therapeutics Assessment By Anti-CD274 (PD-L1) Antibody Therapeutics Route of Administration: Oral, Intravenous, Inhalation, Subcutaneous, Parenteral
- Therapeutics Assessment By Anti-CD274 (PD-L1) Antibody Therapies Molecule Type: Gene therapy, Stem cell therapy, Small molecules
- Therapeutics Assessment By Anti-CD274 (PD-L1) Antibody Therapies Mechanism of Action: Programmed cell death-1 ligand-1 inhibitors
- Key Anti-CD274 (PD-L1) Antibody Companies: Compass Therapeutics, Curis, Biotheus, RemeGen, Incyte Corporation, Jubilant Therapeutics, ChemoCentryx, ABL Bio, Chia Tai Tianqing Pharmaceutical, Jiangsu Hengrui Medicine, Sorrento Therapeutics, CStone Pharmaceuticals, Celgene, Checkpoint Therapeutics, Alphamab Oncology, Eli Lilly and Company, Novartis Pharmaceuticals, Aurigene Discovery Technologies, Arbutus Biopharma, CytomX Therapeutics, Genmab A/S, Secarna Pharmaceuticals, Avacta Life Sciences Limited, Fate Therapeutics, Hanmi Pharm.Co., Celldex Therapeutics, Bolt Biotherapeutics, Bio-Thera Solutions, Acepodia Inc., Janux Therapeutics, Coherus Biosciences, Effector Therapeutics, Palleon Pharmaceuticals, F-star Therapeutics, BeiGene, and many others.
- Key Anti-CD274 (PD-L1) Antibody Pipeline Therapies: CTX-8371, CA 327, RC 98, PM 8001, INCB086550, CCX 559, ABL501, TQB 2450, SHR 1316, FS222, SHR-1701, Cosibelimab, LY 3434172, KN035, KN046, CX-072, GEN1046, AVA028, AVA021, PD-L1 XT, FT516, FT500, CDX 527, Envafolimab, BGB-A333, ACE1708, Tomivosertib, and others.
Dive deep into rich insights for emerging therapies and assessment, visit @ https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight
View Report: https://www.delveinsight.com/report-store/anti-cd274-pd-l1-antibody-pipeline-insight
Table of Contents
| 1 | Introduction |
| 2 | Executive Summary |
| 3 | Anti-CD274 (PD-L1) Antibody: Overview |
| 4 | Pipeline Therapeutics |
| 5 | Late Stage Products (Preregistration) |
| 5.1 | Socazolimab: Sorrento Therapeutics |
| 5.2 | GB226: Genor Biopharma |
| 6 | Late Stage Products (Phase III) |
| 6.1 | Cosibelimab: Checkpoint Therapeutics |
| 6.2 | SHR-1701: Jiangsu Hengrui Medicine |
| 7 | Mid Stage Products (Phase II) |
| 7.1 | Tomivosertib: Effector Therapeutics |
| 7.2 | INCB086550: Incyte Corporation |
| 7.3 | PM 8001: Biotheus |
| 8 | Early Stage Products (Phase I/II) |
| 8.1 | BGB-A333: BeiGene |
| 9 | Early Stage Products (Phase I) |
| 9.1 | ABL501: ABL Bio |
| 10 | Preclinical Stage Products |
| 10.1 | CTX-8371: Compass Therapeutics |
| 11 | Therapeutic Assessment |
| 12 | Inactive Products |
| 13 | Collaborations Assessment- Licensing / Partnering / Funding |
| 14 | Anti-CD274 (PD-L1) Antibody- Unmet Needs |
| 15 | Anti-CD274 (PD-L1) Antibody- Market Drivers and Barriers |
| 16 | Appendix |
| 17 | About DelveInsight |
For further information on the Anti-CD274 (PD-L1) Antibody current pipeline therapeutics, reach out @ Anti-CD274 (PD-L1) Antibody Ongoing Clinical Trials
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